The Role of High Performance, Grid and Cloud Computing in High-Throughput Sequencing

Lightbody, Gaye; Browne, Fiona; Zheng, Huiru; Haberland, Valeriia; and Blayney, Jaine. 2016. 'The Role of High Performance, Grid and Cloud Computing in High-Throughput Sequencing'. In: Proceedings of the 2016 IEEE International Conference on Bioinformatics & Biomedicine. Shenzhen, China 15-18 December, 2016. [Conference or Workshop Item]
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We have reached the era of full genome sequencing using high throughput sequencing technologies pouring out gigabases of reads in a day. To fully benefit from such a profusion of data high performance tools and systems are needed to extract the information lying within the sequences. This paper provides an overview of the evolution of high-throughput sequencing and the tools, infrastructure and data management developing in this space to support a key area in personalized medicine. The paper concludes by providing an outlook in the future of such technologies and their applications and how they might shape clinical governance.


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