Individual differences in the number of mitochondrial DNA copies: the effect of socio-demographic factors

Differences in mtDNA copy-number are caused by a complex effect of various environmental factors including chemical, biological or physiological stress, age, and embryonic development. However, to date it remains unknown, which factors and at what age have the most significant impact on mtDNA copy-number and cause greater allostatic load. Therefore, the present study aims to assess the involvement of various socio-demographic parameters in manifesting mtDNA copy-number in healthy individuals aged 18-25 years (N=1065). Within the framework of this study the effects of childhood maltreatment and age on individual differences in mitochondrial DNA copy number were revealed.